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KMID : 0811720060100000331
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Korean Journal of Physiology & Pharmacology
2006 Volume.10 No. 0 p.331 ~ p.0
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THE PURPOSE OF THIS STUDY WAS TO EXAMINE THE EFFECT OF DAILY EXERCISE BEFORE STEROID TREATMENT ON MASS, TYPE I AND II FIBER CROSS-SECTIONAL AREA, AND MYOFIBRILLAR PROTEIN CONTENT OF HINDLIMB MUSCLES IN A RAT MODEL
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Choe Myoung-Ae
An Gyeong-Ju
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Abstract
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Muscle atrophy following steroid therapy is common problem in chronic diseases. Previous studies have examined that exercise during and following steroid therapy may reduce steroid induced muscle atrophy. However, there have been few
studies to determine the effect of exercise before steroid therapy on muscle changes. The purpose of this study was to examine the effect of daily exercise before steroid treatment on mass, type I and II fiber cross-sectional area, and myofibrillar protein content of hindlimb muscles in a rat model. Adult male Sprague-Dawley rats (200～220 g body weight)
were randomly assigned to one of three groups (n=10/group): a control group (n=10) that had normal saline injection for 7
days; a steroid group (n=10) that had steroid injection for 7 days; an exercise-steroid group (n=10) that ran on the treadmill
for 7 days before steroid treatment). Rats in the exercise group had 14 sessions of exercise; rats ran on a treadmill for 30 minutes, 2 times per day at 10m/min and grade 10. Body weight and food intake were measured every day. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles were dissected. Body weight, food intake, muscle weight, fiber type distribution, cross-sectional area, and myofibrillar protein content of the dissected muscles were
determined. The exercise-steroid group showed significant increases (p .05) as compared with the steroid rats in body
weight, muscle weight of soleus and gastrocnemius, type II fiber cross-sectional area of plantaris and gastrocnemius muscles, and myofibrillar protein content of soleus, plantaris, and gastrocnemius muscles. As compared with the control group. the steroid group showed significant decreases (p .05) in body weight and diet intake, muscle weight of soleus, plantaris, and gastrocnemius, type II fiber cross-sectional area of soleus, plantaris, and gastrocnemius muscles, and myofibrillar protein content of soleus, plantaris, and gastrocnemius muscles. Daily exercise before steroid administration attenuates hindlimb muscle atrophy. The effects of exercise are more pronounced in the plantaris and gastrocnemius as compared to the soleus muscle.
Source: Korean J Physiol Pharmacol.2006 Oct;10(Suppl II):241
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KEYWORD
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steroid, exercise, muscle weight, type I and II fiber cross-sectional area, myofibrillar protein content, hindlimb muscle, rat
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